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In this issue of Blood, [Wang et al][1] report correction of the bleeding phenotype in newborn and adult factor IX (FIX) knockout mice through in vivo gene editing mediated by clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9).[1][2] This technology
1936 (LBC) (Deary et al. 2004, 2007, 2012; Taylor et al. 2018) are both part of a longitudinal study on cognitive ag-ing. Participants were all born in 1921 or 1936, and com- ... (Aryee et al. 2014). 578 V. K. Chundru et al. Probeswithlowdetectionrate(,95%atP,0.01),andlow-quality samples were removed. Individuals with low call rate
Brief et al. (1997) and Morling and Kitayama (2008) support the argument that family is the motivation to work in North America and Southeast Asia. To further investigate the above
Determinants of creative or innovative behavior among frontline employees have been examined rarely in the literature, which is unfortunate as such information may help managers to benefit from their employees' potentials. This study first identifies conceptually transformational leadership and ...
organization" (Goldman, 2008; Vreja et al., 2016). Lipman-Blumen (2005) describes toxic leaders as "those who act without integrity by dissembling and engaging in various other
While there is evidence of a connection between mentoring and organizational commitment in the broader literature (Aryee et al., 1994, Donaldson et al., 2000, Payne and Huffman, 2005, Scandura, 1997), the relationship takes on additional complexity in the family firm context. By addressing the mentoring relationship in the context of family ...
Aryee et al. BMC Public Health (2018) 18:1292 Page 2 of 8. ahead. The model with the minimum errors was consid-ered accurate for prediction but the best model does may not necessarily give the best forecasting errors. Results The monthly TB time-dependent data consisted of 120
1936 (LBC) (Deary et al. 2004, 2007, 2012; Taylor et al. 2018) are both part of a longitudinal study on cognitive ag-ing. Participants were all born in 1921 or 1936, and com- ... (Aryee et al. 2014). 578 V. K. Chundru et al. Probeswithlowdetectionrate(,95%atP,0.01),andlow-quality samples were removed. Individuals with low call rate
Aryee et al. BMC Public Health (2018) 18:1292 Page 2 of 8. ahead. The model with the minimum errors was consid-ered accurate for prediction but the best model does may not necessarily give the best forecasting errors. Results The monthly TB time-dependent data consisted of 120
PAX6 methylation significantly predicts depressive symptomatology in children (Kaufman et al., 2018) and plays a key role in neurogenesis and differentiation of dopaminergic neurons (de Chevigny et al., 2012). PLEKHGS is involved in neuronal cell differentiation and is associated with motor neuron disease (Maystadt et al., 2007).
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Asteroid mining is the exploitation of raw materials from asteroids and other minor planets, including near-Earth objects.. Hard rock minerals could be mined from an asteroid or a spent comet. Precious metals such as gold, silver, and platinum group metals could be transported back to Earth, whilst iron group metals and other common ones could be used for construction in space.
In this issue of Blood, [Wang et al][1] report correction of the bleeding phenotype in newborn and adult factor IX (FIX) knockout mice through in vivo gene editing mediated by clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9 (CRISPR/Cas9).[1][2] This technology
Although many studies have suggested that the relationship between different supply chain members significantly affects agricultural product quality, suppliers' perceptions of fairness, which greatly influence their decisions on building the relationship quality, are often overlooked. Particularly, the empirical evidence to investigate the impacts of suppliers’ fairness on the ...
(Kersley et al., 2005; US Bureau of Labor, 2007), research on the organizational effects of such practices is not well integrated. Competing demands between work and home have assumed increased relevance for employees in recent years, due in large part to demographic and workplace changes such as rising numbers of women in the
Ed Wensing National Centre for Indigenous Studies, The Australian National University, Canberra, ACT, Australia; Centre for Tropical Urban and Regional Planning, College of Science and Engineering, James Cook University, Cairns, Queensland, Australia; Australian Institute of Aboriginal and Torres Strait Islander Studies, Canberra, ACT, Australia Correspondence [email protected]
Midwifery publishes the latest peer reviewed international research to inform the safety, quality, outcomes and experiences of pregnancy, birth and maternity care for childbearing women, their babies and families. The journal's publications support midwives and maternity care providers to explore and develop their knowledge, skills and attitudes informed by best available evidence.
Article Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics Graphical Abstract Highlights d Somatic mtDNA mutations can track cellular relationships and hierarchies in .
Jun 14, 2019· Such tools are theoretically suitable for the analysis of most sequencing data types, including chromatin immunoprecipitation and Hi-C, leading to the development of wrapper packages around DESeq and EdgeR that facilitate differential analyses for such data (Lareau and Aryee, 2018; Ross-Innes et al., 2012).
Apr 14, 2018· A recent pancancer study of DNA-methylation (Gevaert et al., 2015) revealed 10 pancancer clusters reflecting new similarities across malignantly transformed tissues. Furthermore, several computational tools have been developed incorporating state-of-the-art statistical techniques for the analysis of DNA methylation data (Aryee et al., 2014).
Volume 16, 2018 - Issue 3. ... Aryee et al. Human Performance. Volume 25, 2012 - Issue 1. Published online: 13 Jan 2012. Article. Two Decades of Research and Development in Transformational Leadership. Bernard M. Bass. European Journal of Work and Organizational Psychology. Volume 8, 1999 - Issue 1. Published online: 10 Sep 2010.
State of the environment (SoE) reporting has been in place in the majority of Australian jurisdictions since the early 1990s. Over the past decade, the process has stalled in Western Australia (WA) and, at present, shows no sign of reappearing. This is all the more serious since the degraded ...
While there is evidence of a connection between mentoring and organizational commitment in the broader literature (Aryee et al., 1994, Donaldson et al., 2000, Payne and Huffman, 2005, Scandura, 1997), the relationship takes on additional complexity in the family firm context. By addressing the mentoring relationship in the context of family ...
(Kersley et al., 2005; US Bureau of Labor, 2007), research on the organizational effects of such practices is not well integrated. Competing demands between work and home have assumed increased relevance for employees in recent years, due in large part to demographic and workplace changes such as rising numbers of women in the
Initiation and Evolution of Early Onset Prostate Cancer Joshua W. Russo1 and Steven P. Balk1,* 1Hematology-Oncology Division, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA *Correspondence: [email protected]
Sep 12, 2018· 1. Nature. 2018 Sep 12. doi: 10.1038/s41586-018-0500-9. [Epub ahead of print] In vivo CRISPR editing with no detectable genome-wide off-target mutations.
Sep 21, 2018· Streptococcus pyogenes Cas9 (SpCas9), the one most often used for genome editing, only recognizes the NGG sequence (where N is any nucleobase) as the PAM, which restricts regions in the genome that can be targeted. To address this limitation, Nishimasu et al. created a SpCas9 variant that recognizes NG rather than NGG.
Sep 12, 2018· 1. Nature. 2018 Sep 12. doi: 10.1038/s41586-018-0500-9. [Epub ahead of print] In vivo CRISPR editing with no detectable genome-wide off-target mutations.
CALEBLAREAU [email protected] ORCID:0000-0003-4179-4807 " ⁄ =7 R ABOUT I'madoctoralcandidateatHarvardMedicalSchoolinterestedinelucidatingthegenetic ...
Apr 14, 2018· A recent pancancer study of DNA-methylation (Gevaert et al., 2015) revealed 10 pancancer clusters reflecting new similarities across malignantly transformed tissues. Furthermore, several computational tools have been developed incorporating state-of-the-art statistical techniques for the analysis of DNA methylation data (Aryee et al., 2014).
